"Clinically predictive preclinical efficacy testing services at your disposal"


Jussi Halleen - CEO, Pharmatest Services

Scientific publications

LIST OF PUBLICATIONS BY PHARMATEST

PUBLISHED SCIENTIFIC PAPERS INCLUDING RESULTS FROM STUDIES PERFORMED IN PHARMATEST

  1. Suominen MI, Fagerlund KM, Rissanen JP, Konkol Y, Morko J, Peng Z, Alhoniemi E, Laine S, Corey E, Mumberg D, Ziegelbauer K, Käkönen S, Halleen JM, Vessella  R. and Scholz A. 2017 Radium-223 Inhibits Osseous Prostate Cancer Growth by Dual Targeting of Cancer Cells and Bone Microenvironment in Mouse Models. Clin Cancer Res 23(15):4335-46.
  2. Konkol Y, Vuorikoski H, Tuomela J, Holmbom Bjarne, Bernoulli J 2017 Galactoglucomannan-rich hemicellulose extract from Norway spruce (Picea abies) exerts beneficial effects on chronic prostatic inflammation and lower urinary tract symptoms in vivo. Int J Biol Macromol 101 222-229.

  3. Konkol Y, Bernoulli J, Streng T, Jääskeläinen K, Laihia J, Leino L 2015 Intravesical treatment with cis-urocanic acid improves bladder function in rat model of acute bladder inflammation. Neurourol Urodyn 35(7):786-91.
  4. Valta M, Fagerlund KM, Suominen MI, Halleen JM, Tuomela J2015 Importance of microenvironment in preclinical models of breast and prostate cancer. World J Pharmacol 4(1):47-57.
  5. Bernoulli J, Konkol Y, Vuorikoski H, Yatkin E 2014 Effects of afala and antiestrogen ICI 182,780 in the model of hormone-dependent prostate inflammation. Bull Exp Biol Med 156(6):807-9.

  6. Suominen MIRissanen JP, Käkönen R, Fagerlund KMAlhoniemi E, Mumberg D, Ziegelbauer K, Halleen JM, Käkönen SM, Scholz A 2013 Survival Benefit With Radium-223 Dichloride in a Mouse Model of Breast Cancer Bone Metastasis. J Natl Cancer Inst 105(12):908-916.
  7. Erlandsson MC, Svensson MD, Jonsson IM, Bian L, Ambartsumian N, Andersson S, Peng Z, Vääräniemi J, Ohlsson C, Andersson KM, Bokarewa MI 2013 Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function.  Biochim Biophys Acta 1833(12):2653-63.
  8. Pollari S, Käkönen RS, Mohammad KS, Rissanen JP, Halleen JM, Wärri A, Nissinen L, Pihlavisto M, Marjamäki A, Perälä M, Guise TA, Kallioniemi O, Käkönen SM 2012 Heparin-like polysaccharides reduce osteolytic bone destruction and tumor growth in a mouse model of breast cancer bone metastasis. Mol Cancer Res 10(5):597-604.
  9. Laajala TD, Corander J, Saarinen NM, Mäkelä K, Savolainen S, Suominen MI, Alhoniemi E, Mäkelä S, Poutanen M, Aittokallio T 2012 Improved statistical modeling of tumor growth and treatment effect in preclinical animal studies with highly heterogeneous responses in vivo. Clin Cancer Res 18(16):4385-96.
  10. Strube A, Suominen MI, Rissanen JP, Mumberg D, Klar U, Halleen JM, Käkönen SM 2011 The anti-tumor agent sagopilone shows antiresorptive effects both in vitro and in vivo. Osteoporos Int (2011) 22:2887–2893.
  11. Neerup TS, Stahlhut M, Petersen JS, Daugaard JR, Jensen JE, Peng ZMorko J, Thorkildsen C 2011 ZP2307, a novel, cyclic PTH(1-17) analog that augments bone mass in ovariectomized rats. Bone 48:1319-1327.
  12. Rissanen JP, Halleen JM 2010 Models and screening assays for drug development in osteoporosis. Expert Opin Drug Discov 5:1163-1174.
  13. Ma H, Torvinen S, Silvennoinen M, Rinnankoski-Tuikka R, Kainulainen H, Morko JPeng Z, Kujala UM, Rahkila P, Suominen H 2010 Effects of diet-induced obesity and voluntary wheel running on bone properties in young male C57BL/6J mice. Calcif Tissue Int 86:411-419.
  14. Tuomela J, Grönroos TJ, Valta MP, Sandholm J, Schrey A, Seppänen J, Marjamäki P, Forsback S, Kinnunen I, Solin O, Minn H, Härkönen PL 2010 Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts. BMC Cancer.30;10:596.
  15. Rissanen JP, Ylipahkala H, Fagerlund KM, Long C, Väänänen HK, Halleen JM 2009 Improved methods for testing antiresorptive compounds in human osteoclast cultures. J Bone Miner Metab 27:105-109.
  16. Tuomela J, Valta M, Seppänen J, Tarkkonen K, Väänänen HK, Härkönen P 2009 Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors. BMC Cancer. 12;9:362.
  17. Rissanen JP, Suominen MIPeng ZHalleen JM 2008 Secreted tartrate-resistant acid phosphatase 5b is a Marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model. Calcif Tissue Int 82:108-115.
  18. Rissanen JP, Suominen MIPeng ZMorko J, Rasi S, Risteli J, Halleen JM 2008 Short-term changes in serum PINP predict long-term changes in trabecular bone in the rat ovariectomy model. Calcif Tissue Int 82:155-161.
  19. Narva M, Rissanen JP, Halleen JM, Vapaatalo H, Väänänen K, Korpela R 2007 Effects of bioactive peptide, valyl-prolyl-proline (VPP), and lactobacillus helveticus fermented milk containing VPP on bone loss in ovariectomized rats. Ann Nutr Metab 51:65-74.

SELECTED OTHER PUBLICATIONS BY PHARMATEST STAFF

  1. Morko J, Kiviranta R, Mulari MT, Ivaska KK, Väänänen HK, Vuorio E, Laitala-Leinonen T 2009 Overexpression of cathepsin K accelerates the resorption cycle and osteoblast differentiation in vitro. Bone 44:717-728.
  2. Yatkin E, Bernoulli J, Lammintausta R, and Santti R 2008 Fispemifene (Z-2-{2-[4-(4 Chloro-1,2-diphenylbut-1-enyl)-phenoxy]ethoxy}-ethanol), a novel selective estrogen receptor modulator, attenuates glandular inflammation in an animal model of chronic nonbacterial prostatitis. J Pharmacol Exp Ther. 327:58-67.
  3. Shen Z, Peng Z, Sun Y, Väänänen HK, Poutanen M 2008 Overexpression of human hydroxysteroid (17beta) dehydrogenase 2 induces disturbance in skeletal development in young male mice. J Bone Miner Res. 23(8):1217-26.
  4. Bernoulli J, Yatkin E, Konkol Y, Talvitie EM, Santti R, and Streng T 2008 Prostatic inflammation and obstructive voiding in the adult Noble rat: Impact of the testosterone to estradiol ratio in serum. Prostate, 68:1296-1306.
  5. Bernoulli J, Yatkin E, Laakso A, Anttinen M, Bosland M, Vega K, Kallajoki M, Santti R and Pylkkänen L 2008 Histopathological evidence for an association of inflammation with ductal PIN-like lesion but not with ductal adenocarcinoma in the prostate of the Noble rat. Prostate, 68:728-739.
  6. Salminen-Mankonen H, Morko J, Vuorio E 2007 Role of cathepsin K in normal joints and in the development of arthritis. Curr Drug Targets 8:315-323. (Review)
  7. Halleen JM, Tiitinen SL, Ylipahkala H, Fagerlund KM, Väänänen HK 2006 Tartrate-resistant acid phosphatase 5b as a marker of bone resorption (Review). Clin Lab 52:499-509.
  8. Morko J, Kiviranta R, Joronen K, Säämänen AM, Vuorio E, Salminen-Mankonen H 2005 Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K. Arthritis Rheum 52:3713-3717
  9. Parikka V, Peng Z, Hentunen T, Risteli J, Elo T, Väänänen HK, Härkönen P. 2005 Estrogen responsiveness of bone formation in vitro and altered bone phenotype in aged estrogen receptor-alpha-deficient male and female mice. Eur J Endocrinol. 152(2):301-14.
  10. Gu G, Mulari M, Peng Z, Hentunen TA, Väänänen HK 2005 Death of osteocytes turns off the inhibition of osteoclasts and triggers local bone resorption. Biochem Biophys Res Commun. 7;335(4):1095-101.
  11. Morko J, Kiviranta R, Hurme S, Rantakokko J, Vuorio E 2005 Differential turnover of cortical and trabecular bone in transgenic mice overexpressing cathepsin K. Bone 36:854-865.
  12. Nenonen A, Cheng S, Ivaska KK, Alatalo SL, Lehtimäki T, Schmidt-Gayk H, Uusi-Rasi K, Heinonen A, Kannus P, Sievänen H, Vuori I, Väänänen HK, Halleen JM 2005 Serum TRACP 5b Is a Useful Marker for Monitoring Alendronate Treatment: Comparison With Other Markers of Bone Turnover. J Bone Miner Res 20:1804-1812.
  13. Kiviranta R, Morko J, Alatalo S, NicAmhlaoibh R, Risteli J, Laitala-Leinonen T, Vuorio E 2005 Impaired bone resorption in cathepsin K deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio. Bone 36:159-172.
  14. Janckila AJ, Parthasarathy RN, Parthasarathy LK, Seelan RS, Hsueh YC, Rissanen JP, Alatalo SL, Halleen JM, Yam LT 2005 Properties and expression of human tartrateresistant acid phosphatase isoform 5a by monocyte-derived cells. J Leukoc Biol. 77(2):209-18.
  15. Gerdhem P, Ivaska KK, Alatalo SL, Halleen JM, Hellman J, Isaksson A, Pettersson K, Väänänen HK, Åkesson K, Obrant KJ 2004 Biochemical markers of bone metabolism and prediction of fracture in elderly women. J Bone Miner Res 19:386-393.
  16. Peng Z, Li X, Mäkelä S, Väänänen HK, Poutanen M 2004 Skeletal changes in transgenic male mice expressing human cytochrome p450 aromatase. J Bone Miner Res.19(8):1320-8.
  17. Savontaus M, Rintala-Jämsä M, Morko J, Rönning O, Metsäranta M, Vuorio E 2004 Abnormal craniofacial development and expression patterns of extracellular matrix components in transgenic Del1 mice harboring a deletion mutation in the type II collagen gene. Orthod Craniofac Res 7:216-226.
  18. Morko J, Söderström M, Säämänen AM, Salminen H, Vuorio E 2004 Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis. Ann Rheum Dis 63:649-655.
  19. Vääräniemi JHalleen JM, Kaarlonen K, Ylipahkala H, Alatalo SL, Andersson G, Kaija H, Vihko P, Väänänen HK 2004 Intracellular machinery for matrix degradation in bone-resorbing osteoclasts. J Bone Miner Res. 19(9):1432-40.
  20. Alatalo SL, Peng Z, Janckila AJ, Kaija H, Vihko P, Vaananen HK, Halleen JM 2003 A novel immunoassay for the determination of tartrate-resistant acid phosphatase 5b from rat serum. J Bone Miner Res. 18(1):134-9.
  21. Kiviranta R, Morko J, Uusitalo H, Aro HT, Vuorio E, Rantakokko J 2001 Accelerated turnover of metaphyseal trabecular bone in mice overexpressing cathepsin K. J Bone Miner Res 16:1444-1452.
  22. Qu Q, Zheng H, Dahllund J, Laine A, Cockcroft N, Peng Z, Koskinen M, Hemminki K, Kangas L, Väänänen K, Härkönen P 2000 Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats. Endocrinology 141(2):809-20.
  23. Halleen JM, Alatalo SL, Suominen H, Cheng S, Janckila AJ, Väänänen HK 2000 Tartrate-Resistant Acid Phosphatase 5b, a Novel Serum Marker of Bone Resorption. J Bone Miner Res 15:1337-1345.
  24. Peng Z, Tuukkanen J, Zhang H, Väänänen HK 1999 Alteration in the mechanical competence and structural properties in the femoral neck and vertebrae of ovariectomized rats. J Bone Miner Res.14(4):616-23.
  25. Kippo K, Hannuniemi R, Laurén L, Peng Z, Kuurtamo P, Virtamo T, Isaksson P, Osterman T, Väänänen HK, Sellman R 1998 Effect of clodronate treatment on established bone loss in ovariectomized rats. Bone. 23(4):333-42.
  26. Jämsä T, Jalovaara P, Peng Z, Väänänen HK, Tuukkanen J 1998 Comparison of three-point bending test and peripheral quantitative computed tomography analysis in the evaluation of the strength of mouse femur and tibia. Bone 23:155-161.
  27. Kippo K, Hannuniemi R, Isaksson P, Laurén L, Osterman T, Peng Z, Tuukkanen J, Kuurtamo P, Väänänen HK, Sellman R 1998 Clodronate prevents osteopenia and loss of trabecular connectivity in estrogen-deficient rats. J Bone Miner Res 13(2):287-96
  28. Osterman T, Laurén L, Kuurtamo P, Hannuniemi R, Isaksson P, Kippo K, Peng Z, Väänänen HK, Sellman R 1998 The effect of orally administered clodronate on bone mineral density and bone geometry in ovariectomized rats. J Pharmacol Exp Ther. 284(1):312-6
  29. Kippo K, Hannuniemi R, Laurén L, Peng Z, Isaksson P, Virtamo T, Osterman T, Pasanen I, Sellman R, Väänänen HK 1997 Clodronate prevents bone loss in aged ovariectomized rats. Calcif Tissue Int. 61(2):151-7.
  30. Peng ZQ, Väänänen HK, Tuukkanen J 1997 Ovariectomy-induced bone loss can be affected by different intensities of treadmill running exercise in rats. Calcif Tissue Int. 60(5):441-8.
  31. Peng ZQ, Väänänen HK, Zhang HX, Tuukkanen J 1997 Long-term effects of ovariectomy on the mechanical properties and chemical composition of rat bone. Bone 20(3):207-12
  32. Peng Z, Tuukkanen J, Väänänen HK 1994 Exercise can provide protection against bone loss and prevent the decrease in mechanical strength of femoral neck in ovariectomized rats. J Bone Miner Res. 9(10):1559-64.
  33. Tuukkanen J, Peng Z, Väänänen HK 1994 Effect of running exercise on the bone loss induced by orchidectomy in the rat. Calcif Tissue Int. 55(1):33-7.
  34. Peng Z, Tuukkanen J, Zhang H, Jämsä T, Väänänen HK 1994 The mechanical strength of bone in different rat models of experimental osteoporosis. Bone 15:523-532.
  35. Tuukkanen J, Peng Z, Väänänen HK 1992 The effect of training on the recovery from immobilization-induced bone loss in rats. Acta Physiol Scand. 145(4):407-11.
  36. Tuukkanen J, Peng Z, Väänänen HK 1991 Effect of exercise on osteoporosis induced by ovariectomy in rats. Calcif Tissue Int. 49 Suppl:S80.