The destabilization of the medial meniscus (DMM) mouse model is a widely used surgical model in osteoarthritis research to study the progression and mechanisms of the degenerative joint disease that affects the cartilage and underlying bone of joints. Researchers use the DMM model to investigate various aspects of osteoarthritis, including the role of inflammation, cartilage degradation, subchondral bone changes, and potential therapeutic interventions. Studying the progression of osteoarthritis in the DMM model can provide insights into the underlying mechanisms of the disease and potential drug targets.
Pharmatest launches a new research model
Pharmatest launches a new DMM research model for studying osteoarthritis that can be used to assess for example knee joint pain/discomfort, degenerative changes in knee joints and bone. The DMM model mimics clinical meniscal injury, a known predisposing factor for the development of human OA, and permits the study of structural and biological changes over the course of the disease. In addition, when applied to genetically modified or engineered mouse models, this surgical procedure permits dissection of the relative contribution of a given gene to OA initiation and/or progression.
Let us know if you would like to receive more information about our new OA model.
