Preclinical mouse models of metastasis play a crucial role in cancer research. These models involve using mice to study the complex process of cancer spreading from the primary tumor to other parts of the body forming metastasis.

Pharmatest offers cell-line derived syngeneic and xenograft models. They are commonly used to model the metastatic processes associated with various types of cancer. 

Syngeneic models, also known as allograft models, involve implanting tumor cells from one strain of mouse into a genetically identical or closely related strain of mouse. The tumor cells and the host mice are from the same species and share similar genetic background. Syngeneic models are particularly valuable for studying the interactions between the immune system and tumors because the immune response in the host can influence tumor growth and treatment outcomes. However, they might not fully represent the complexity of human cancers.

In xenograft models, human tumor cells or tissues are implanted into immunodeficient mice, which lack a functional immune system. Xenograft models using human cells offer insights into human-specific tumor behavior but lack a functional immune system, which can limit the understanding of immunological responses to the tumor.