Breast cancer in vivo models
Expertise in breast cancer metastasis models
Breast cancer metastasis models are suitable for testing the efficacy of drug compounds against several dissemination processes and growth in specific microenvironments. The metastasis models are demanding for the drug candidate, but they have an excellent clinical predictivity. Our intracardiac breast cancer bone metastasis models are clinically predictive models of cancer-induced bone disease. Radiography and dynamic fluorescence imaging reveal the progression of the disease. The data is analyzed for tumor burden, and in bone metastasis studies also bone lesion number and area. Histological bone samples can be analyzed for tumor area, trabecular bone area and osteoclast number to reveal detailed information about the test compound’s effects on bone metastases.