Humanized mouse models

Humanized mouse models contain functional human immune system, which allows their use in preclinical drug development of immunotherapies. Pharmatest offers efficacy studies in oncology in humanized mouse models, and developing such models is a high priority in our current R&D activities. Having special expertise on bone metastasis, our primary focus is in developing models mimicking bone metastatic growth in patients.  However, we also develop and offer other cancer models based on customer needs.

Bone metastases are common and increase mortality in many cancers. Bone provides an essential and natural site for testing immunotherapies as bone marrow is the reservoir of hematopoietic stem cells, the precursors of all immune cells. Bone microenvironment changes tumor properties and induces drug resistance, highlighting the importance of confirming cancer drug efficacy in bone metastasis models before entering clinical trials. This should substantially decrease the currently very high failure rates of cancer drug candidates in clinical trials due to poor efficacy on advanced cancers.